Cervello Therapeutics

About Us

Cervello Therapeutics was created with an emphasis on finding a cure for a rare medical condition, Cerebral Cavernous Malformation (CCM). Tony Varano, with his established reputation of running a clinical software and services organization (DSG), teamed up with an entrepreneurial drug hunter, Matt Lee, who had just stepped away from his position as Senior Director of Drug Discovery at Mirati Therapeutics after playing a key role in the design of their KRas G12C inhibitor MRTX849, with a dream to build a biotech company from the ground-level.

This privately-held company was established with a virtual drug discovery business paradigm, to capitalize on the global contract research organization resources, investing in companies that focus on specific research areas, rather than investing internally in expert staff across the wide range of functional areas needed for drug discovery.

Waylon’s Story

Waylon was a one-year old boy. He experienced his first episode of seizure at the age of one and was consequently diagnosed with a severe familial form of CCM that required surgical intervention to have the malformations and lesions removed within a day. This would be the first of four brain surgeries Waylon would undergo by the age of four to remove the hemorrhagic malformations. Tony Varano, who has known Waylon since he was just a few months old, was determined to find a cure for CCM, which ultimately resulted in the conception of Cervello Therapeutics.

Cervello Therapeutics What is Cerebral Cavernous Malformation (CCM)?

According to Angioma Alliance, a patient advocacy organization for patients with CCM, CCM is a genetic disease present in up to 1.5 million individuals in the United States. Cerebral Cavernous Malformations (CCMs) are collections of small blood vessels in the brain that are enlarged and irregular in structure which lead to altered blood flow within the human body. While these malformations can occur anywhere in the body, for approximately 60,000 patients in the United States, CCMs occur in the brain. The symptoms associated with CCM are seizures, vision and hearing loss, paralysis, other focal neurologic deficits and/or hemorrhagic stroke. The symptoms are usually severe in nature.

Our Mission

Our mission is driven by passion to cure a loved one afflicted with a severe form of the debilitating disease, Cerebral Cavernous Malformation (CCM).

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